Journal article
Mother's smoking and complex lung function of offspring in middle age: A cohort study from childhood
JL Perret, H Walters, D Johns, L Gurrin, J Burgess, A Lowe, B Thompson, J Markos, S Morrison, P Thomas, C McDonald, R Wood-Baker, J Hopper, C Svanes, G Giles, M Abramson, M Matheson, S Dharmage
Respirology | WILEY | Published : 2016
DOI: 10.1111/resp.12750
Abstract
Background and objective: Existing evidence that supports maternal smoking to be a potential risk factor for chronic obstructive pulmonary disease (COPD) for adult offspring has barely been mentioned in major guideline documents, suggesting a need for more robust and consistent data. We aimed to examine whether such early life exposure can predispose to COPD in middle age, possibly through its interaction with personal smoking. Methods: The fifth-decade follow-up of the Tasmanian Longitudinal Health Study cohort, which was first studied in 1968 (n = 8583), included a 2004 postal survey (n = 5729 responses) and subsequent laboratory attendance (n = 1389) for comprehensive lung function testin..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
We acknowledge the TAHS study participants and previous investigators. We thank Professor Mark Jenkins, PhD, Centre for Epidemiology & Biostatistics, The University of Melbourne, Victoria, and Dr Iain Feather, Gold Coast Hospital, Queensland, who are TAHS investigators but not co-authors of this manuscript, for their assistance with obtaining funds and data collection. We also acknowledge all the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland and New South Wales; the research interviewers and data entry operators and the organizational roles of Ms Cathryn Wharton and Dr Desiree Meszaros. Furthermore, we thank the late Jeff Pretto for converting our gas transfer factor and lung volume data to z-scores, and to Professor Philip Quanjer from the Global Lung Function Initiative for converting the spirometric data and providing comment on the manuscript. Finally, we thank the Archives Office of Tasmania for providing data from the 1968 and 1974 TAHS questionnaires and copies of the school medical records. This study was supported by the National Health and Medical Research Council of Australia, research grant 299901; The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland & Tasmanian Asthma Foundations; The Royal Hobart Hospital; Helen MacPherson Smith Trust; GlaxoSmithKline and John L Hopper. J.L.P. is supported by an Australian Postgraduate Award and the Lung Foundation Australia. S.C.D., M.C.M., A.J.L., E.H.W., J.A.B. and J.L.H. are supported by the NHMRC of Australia. The funding agencies had no direct role in the conduct of the study, the collection, management, statistical analysis and interpretation of the data, preparation or approval of the manuscript.